| Dataset:21251873 Search Result | ||||||||||||||||||||||||||||||||||||||||||||
| Clinical Information | ||||||||||||||||||||||||||||||||||||||||||||
| Detailed clinical information for 3 patients with OsR influenza A pandemic (H1N1) 2009. | ||||||||||||||||||||||||||||||||||||||||||||
| PatientAge, sex | Healthcare setting | Underlying conditions setting | Date of illness | Details of NAI therapy onset | Influenza A/subtyping/OsR testing | Duration Os therapy prior to onset OsR | Change in therapy due to OsR | Duration of shedding | Outcome | Other clinical information | ||||||||||||||||||||||||||||||||||
| Test date | Resul | |||||||||||||||||||||||||||||||||||||||||||
| 1 25 years, M | ICU | Haematological malignancy,
bone marrow transplantation |
August 9, 2009 | Os, August 10–20 | August 9 | H1N1 2009/H275 | 24 days intermittent therapy | None | 16 days | Recovered | Parainfluenza coinfection was detected in August 17 and 24 samples. Discharged, readmitted 2 weeks later with fatal EBV infection. Family member had respiratory illness prior to onset of illness in patient. September 7 sample with H275Y mutation was first detected in early October when screened at Ontario PHL as part ofsurveillance testing | |||||||||||||||||||||||||||||||||
| August 17 | FluA | |||||||||||||||||||||||||||||||||||||||||||
| August 24 | H1N1 2009/H275Y | 18 days | Zanamivir | 18 days | Recovered | October 22 sample tested by rapid test only. Admitted with pneumonia. On steroids for SLE; had concomitant Salmonella Group B bacteremia.Patient made a complete recovery. No reports of respiratory illness in contacts | ||||||||||||||||||||||||||||||||||||||
| Os, August 25–September 18 | September 1 | H1N1 2009/H275Y | ||||||||||||||||||||||||||||||||||||||||||
| September 7 | H1N1 2009/H275Y | |||||||||||||||||||||||||||||||||||||||||||
| September 9 | FluA not detected | |||||||||||||||||||||||||||||||||||||||||||
| Os, September 25–27 | September 24 | FluA not detected | ||||||||||||||||||||||||||||||||||||||||||
| 2 33 years, F | ICU | Lupus, asthma, hypertension | October 22, 2009 | Os October 22–November 10 | October 22 | FluA | ||||||||||||||||||||||||||||||||||||||
| October 28 | H1N1 2009/H275 | |||||||||||||||||||||||||||||||||||||||||||
| November 9 | H1N1 2009/H275Y | |||||||||||||||||||||||||||||||||||||||||||
| November 16 and 17 | FluA not detected | |||||||||||||||||||||||||||||||||||||||||||
| November 20 | FluA not detected | |||||||||||||||||||||||||||||||||||||||||||
| 3 9 years, F | Oncology ward | Haematological malignancy | June 13, 2009 | Os, June 14–19 | June 13 | H1N1 2009/H275 | 10 days | No antivirals given | 122 days | Recovered | Resistance first detected when samples from December 1, 2009 were tested due to persistent shedding of virus at the treating clinician’s request. Well at time of detection of OsR strain. Subsequently earlier samples were forwarded to Ontario PHL and resistance was confirmed on allsamples since first detected on July 30, 2009. No reports of respiratory illness in contacts | |||||||||||||||||||||||||||||||||
| Os, June 30–July 5 | July 30 | H1N1 2009/H275Y | ||||||||||||||||||||||||||||||||||||||||||
| Os, August 4–14 | August 26 | H1N1 2009/H275Y | ||||||||||||||||||||||||||||||||||||||||||
| September 8 | H1N1 2009/H275Y | |||||||||||||||||||||||||||||||||||||||||||
| December 1 | H1N1 2009/H275Y | |||||||||||||||||||||||||||||||||||||||||||