Dataset:25042157 Search Result
Clinical Information
Epidemiological, Clinical, and Laboratorial Information Concerning the Three Cases From 2010/2011 Suspected of Clinical Resistance Development to Oseltamivir
Case number	1	2	3
Epidemiological and clinical information
Patient
Age (years)	1	27	61
Gender	Male	Female	Male
Underlying risk conditions	Premature bronchopulmonary
	dysplasia (hospitalized since birth)	HIVþ; pregnant	Not referred
Clinical disease	Severe	Severe with loss of the fetus	Severe
Influenza antiviral drug treatment
Antiviral drug	Oseltamivir	Oseltamivir	Oseltamivir
Starting date	11 days after the 1st positive rt RT-PCR	Not referred	Not referred
Evidence of failure	rt RT-PCR positive after 15 days of treatment	Not referred	rt RT-PCR positive after 10 days of treatment
Time between the start of antiviral therapy and specimen collection	20 days	Not possible to estimate	≥10 days
Clinical outcome	Not referred	Deceased	Not referred
Other observations	—	Initiated treatment with zanamivir; from Guinea (Africa)	Not referred
Clinical specimen laboratorial results H275Y oseltamivir-resistant marker	Not present	Present (Ct ¼ 13)	Present as quasi-species (Ct ¼ 27 for 275Y; Ct ¼ 28 for 275H), representing 26.2% of the virus population
Virus strain isolated	No strain isolated	A/Portugal/03/2011	No strain isolated