Dataset:27714496 Search Result
Clinical Information
Demographic characteristics and viral investigation of five patients infected with H275Y mutant viruses in 2016
Cases			Case 1	Case 2	Case 3	Case 4	Case 5
Patient information	Age (years)		75	41	37	1	2
	Sex		Female	Male	Female	Female	Female
	Area in Japan		Niigata	Nagasaki	Nagasaki	Niigata	Niigata
	Date of fever onset		25-Jan	9-Jan	10-Jan	5-Feb	12-Feb
	Date of therapy start		25-Jan	11-Jan	11-Jan	6-Feb	12-Feb
	NAIs used		Peramivir	Oseltamivir	Peramivir	Oseltamivir	Oseltamivir
	Fever duration(days)		1	1	3	3	2
	Travel history		No	No	Yesa	No	No
	History of NAI treatment		Yesb	No	No	No	No
			Oseltamivir
	Underlying condition		Yesc	No	No	No	No
	Hospitalization		Yesc	No	No	No	No
Viral investigations	Date of sample collection		25-Jan	11-Jan	11-Jan	6-Feb	12-Feb
	Strain name		A/Niigata/15NU001/2016	A/Nagasaki/15N002/2016	A/Nagasaki/15N005/2016	A/Niigata/15F255/2016	A/Niigata/15F341/2016
	Neuraminidase inhibition assay	Oseltamivir	353.38 ± 13.32	321.59 ± 19.81	352.59 ± 23.03	320.38 ± 50.33	346.31 ± 44.37
	(IC50) [nM]d	Peramivir	19.67 ± 2.82	23.88 ± 1.72	22.30 ± 0.83	20.10 ± 1.68	18.77 ± 0.70
		Zanamivir	0.74 ± 0.03	0.74 ± 0.04	0.69 ± 0.07	0.79 ± 0.042	0.69 ± 0.08
		Laninamivir	0.83 ± 0.03	0.74 ± 0.02	0.75 ± 0.01	0.94 ± 0.13	0.84 ± 0.07
	NA enzyme kinetics parametere	Km [μM]	33.42 ± 5.15	73.22 ± 27.65	61.79 ± 12.10	29.48 ± 4.78	27.04 ± 3.02
		Vmax[μM/min]	0.33 ± 0.02	0.56 ± 0.31	0.40 ± 0.03	0.45 ± 0.06	0.31 ± 0.02