AVM

Protein name	Nucleocapsid Phosphoprotein
Uniprot protein ID	P0DTC9
Protein length	419 amino acids
Protein description	The Nucleocapsid Phosphoprotein has a modular organization which can be divided into intrinsically disordered regions (IDRs) and conserved structural regions according to the sequence characteristics. The IDRs include three modules: N-arm, central Ser/Arg-rich flexible linker region (LKR), and C-tail, while the conserved structural regions including two modules: N-terminal domain (NTD) and C-terminal domain (CTD). In the primary structure, NTD and CTD are connected by LKR and are usually flanked by N-arm and C-tail. The nucleocapsid phosphoprotein is a structural protein that binds to, protects the viral RNA genome and is involved in packaging the RNA into virus particles. The N protein has been suggested as an antiviral drug target.

Pubmed ID	34431705
Clinical information	No
Disease	-
Published year	2021
Journal	Microbiology spectrum
Title	Identification of Novel Mutations in the N Gene of SARS-CoV-2 That Adversely Affect the Detection of the Virus by Reverse Transcription-Quantitative PCR
Author	Rashedul Hasan, Mohammad Enayet Hossain, Mojnu Miah, Md Mahmudul Hasan, Mustafizur Rahman
Evidence	Interestingly, one nucleotide substitution (G28314T) was also observed in the probe-binding region for the U.S. CDC nCoV N1 RT-qPCR assay, although the mismatch did not impair detection in the confirmatory test (Fig. 1A).