Mutation detail:
| Mutation site | K443S |
| Virus | Varicella-Zoster virus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF4 |
| Gene ID | 1487672 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | AB097933.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Multifunctional Expression regulator |
| Uniprot protein ID | P09269 |
| Protein length | 452 amino acids |
| Protein description | VZV ORF4 encodes an approximately 51-kDa phosphoprotein (25), which is present in the virion tegument. VZV ORF4 protein is present in the nucleus early in infection and later localizes predominantly to the cytoplasm. When ORF4 protein is coexpressed with ORF62 protein, the former localizes to the nucleus. ORF4 encodes an immediate-early (IE) protein that transactivates expression of certain putative immediate-early, early, and late VZV genes. The protein acts in concert with the ORF62 protein to transactivate multiple viral promoters. ORF4 protein likely works at both the transcriptional and posttranscriptional levels. Transcriptional activation requires dimerization of the ORF4 protein. |
Literature information:
| Pubmed ID | 14581575 |
| Clinical information | No |
| Disease | - |
| Published year | 2003 |
| Journal | JOURNAL OF VIROLOGY |
| Title | Requirement of Varicella-Zoster Virus Immediate-Early 4 Protein for Viral Replication |
| Author | Bunji Sato,Marvin Sommer,Hideki Ito,Ann M. Arvin |
| Evidence | line 6, insertion of the ORF4 gene coding for the K443S mutation into pvSpe23.FIG.1 |