Mutation detail:
| Mutation site | C96G |
| Virus | Human respiratory syncytial virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | M2 |
| Gene ID | 1494476 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | A |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | M74568.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | 0 |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Matrix (M2/22K) |
| Uniprot protein ID | P04545 |
| Protein length | 194 amino acids |
| Protein description | Matrix (M2/22K) acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription. Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription. Preferentially binds to poly(A)-rich sequences. Matrix (M2/22K) plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate host NF kappa-B through association with host RELA. |
Literature information:
| Pubmed ID | 11689613 |
| Clinical information | No |
| Disease | - |
| Published year | 2001 |
| Journal | Journal Of Virology |
| Title | Requirement of cysteines and length of the human respiratory syncytial virus M2-1 protein for protein function and virus viability |
| Author | R S Tang, N Nguyen, X Cheng, H Jin |
| Evidence | rA2-C96G and rA2-Tr17 were evaluated for their abilities to replicate in the respiratory tracts of cotton rats.The replication of rA2-C96G was reduced by approximately 1.3 log10 compared to that of rA2. |