Mutation detail:
| Mutation site | H453S |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | PB2 |
| Gene ID | 23308131 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | CY147325.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Polymerase PB2 |
| Uniprot protein ID | C3W5X5 |
| Protein length | 759 amino acids |
| Protein description | PB2 plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. |
Literature information:
| Pubmed ID | 20129961 |
| Clinical information | No |
| Disease | - |
| Published year | 2010 |
| Journal | J Clin Microbiol |
| Title | Genetic makeup of amantadine-resistant and oseltamivir-resistant human influenza A/H1N4 viruses |
| Author | Hassan Zaraket,Reiko Saito,Yasushi Suzuki,Tatiana Baranovich,Clyde Dapat |
| Evidence | oseltamivir-susceptible and -resistant viruses of subclades 2B.I and 2C: for PB2, the H453S mutation; for PB1, the N642S mutation (only viruses from the 2008-2009 season) |