Mutation detail:
Mutation site | I123V |
Virus | Influenzavirus A H1N1 |
Mutation level ![]() |
Amino acid Level |
Gene/protein/region type | NS1 |
Gene ID | 23308111 |
Country | Netherlands |
Mutation type ![]() |
nonsynonymous mutation |
Genotype/subtype/clade | - |
Sample ![]() |
Human |
Variants | - |
Viral reference sequence | FJ966086.1 |
Drug/antibody/vaccine | - |
Transmissibility ![]() |
- |
Transmission mechanism | - |
Pathogenicity ![]() |
- |
Pathogenicity mechanism | - |
Immune escape mutation | - |
Immune escape mechanism | - |
RT-PCR primers probes | - |
Protein detail:
Protein name | Nonstructural Protein 1 |
Uniprot protein ID | C3W611 |
Protein length | 219 amino acids |
Protein description | The non-structural protein 1 (NS1) is a crucial influenza A virus immune regulator that antagonizes antiviral response. The NS1 protein counteracts the production of IFNs and the activities of IFN-induced proteins that restrict influenza virus replication. Furthermore, NS1 is a multifunctional regulatory viral protein that plays a critical role as a posttranscriptional regulatory factor in the life cycle of influenza virus; specifically, binding virion RNA. NS1 protein consists of 2 distinct functional domains connected by a flexible linker region (LR): an N-terminal RNA- binding domain (RBD, aa 1-73) and a C-terminal effector domain (ED, aa 74-207). The nucleotide sequence (NLS) (aa 35-41) overlaps the sequences needed for dsRNA binding. |
Literature information:
Pubmed ID | 24699508 |
Clinical information | No |
Disease | - |
Published year | 2014 |
Journal | PLoS One |
Title | Mass spectrometry-based comparative sequence analysis for the genetic monitoring of influenza A(H1N1)pdm17 virus |
Author | Jairo Gooskens,Jessika C Zevenhoven-Dobbe,Eric C Claas,Aloys C M Kroes,Clara C Posthuma |
Evidence | The majority of SNPs (246/456) resulted in silent mutations and few SNPs (210/456) encoded for non-relevant amino acid substitutions in NA gene (V106I (n=61), V203M (n=1), N248D (n=62), S286G (n=1)), PB1-F2 gene (T34A (n=1), V113A(n=1)), PB2 gene (K660R (n=2)) and NS1 gene segments (I123V (n=61), N133D (n=16), S135N (n=1), G154R (n=1), V194I (n=1), D207N (n=1)). The degree of discordance was limited (31/487 SNPs) and only 21 amino acid substitutions differed among the results generated by MSCSA and Sanger sequencing. |