AVM v1, released 02-OCT-22

A manually curated database of aerosol-transmitted virus mutations, human diseases, and drugs

Mutation detail:


Mutation site K660R
Virus Influenzavirus A H1N1
Mutation level Amino acid Level
Gene/protein/region type PB2
Gene ID 23308131
Country Netherlands
Mutation type nonsynonymous mutation
Genotype/subtype/clade -
Sample Human
Variants -
Viral reference sequence FJ966079.1
Drug/antibody/vaccine -
Transmissibility -
Transmission mechanism -
Pathogenicity -
Pathogenicity mechanism -
Immune escape mutation -
Immune escape mechanism -
RT-PCR primers probes -

Protein detail:


Protein name Polymerase PB2
Uniprot protein ID C3W5X5
Protein length 759 amino acids
Protein description PB2 plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.

Literature information:


Pubmed ID 24699508
Clinical information No
Disease -
Published year 2014
Journal PLoS One
Title Mass spectrometry-based comparative sequence analysis for the genetic monitoring of influenza A(H1N1)pdm16 virus
Author Jairo Gooskens,Jessika C Zevenhoven-Dobbe,Eric C Claas,Aloys C M Kroes,Clara C Posthuma
Evidence The majority of SNPs (246/456) resulted in silent mutations and few SNPs (210/456) encoded for non-relevant amino acid substitutions in NA gene (V106I (n=61), V203M (n=1), N248D (n=62), S286G (n=1)), PB1-F2 gene (T34A (n=1), V113A(n=1)), PB2 gene (K660R (n=2)) and NS1 gene segments (I123V (n=61), N133D (n=16), S135N (n=1), G154R (n=1), V194I (n=1), D207N (n=1)). The degree of discordance was limited (31/487 SNPs) and only 21 amino acid substitutions differed among the results generated by MSCSA and Sanger sequencing.