Mutation detail:
| Mutation site | E628G/I1154V/I1493V/V1725I |
| Virus | Measles virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | L |
| Gene ID | 1489802 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | AB016162.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Large Polymerase Protein |
| Uniprot protein ID | P12576 |
| Protein length | 2183 amino acids |
| Protein description | The viral polymerase (an RNA-dependent RNA polymerase, RdRp) or large protein is coded by the L gene. It catalyzes RNA synthesis, polymerization, capping, polymerization, methylation and polyadenylation. The negative sense RNA is transcribed directly into mRNA without forming any DNA intermediate. |
Literature information:
| Pubmed ID | 33916225 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Viruses |
| Title | Mutated Measles Virus Matrix and Fusion Protein Influence Viral Titer In Vitro and Neuro-Invasion in Lewis Rat Brain Slice Cultures |
| Author | Johannes Busch,Soroth Chey,Michael Sieg,Thomas W Vahlenkamp,Uwe G Liebert |
| Evidence | Only correct plasmids were used to rescue the virus. Generated virus mutant strains were named by the mutations they harbored: MV-M(T120A), MV-F(I225M), MV-M/F(T120A)/(I225M), MV-M(R293Q) and MV-L(E628G/I1154V/I1493V/V1725I), from here on designated MV-L |