Mutation detail:
| Mutation site | E89K |
| Virus | Measles virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | M |
| Gene ID | 1489803 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | GQ376026.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
increase |
| Pathogenicity mechanism | Virus replication kinetics are shown in Fig. (22); the MV99YC7 strain possessed higher replication efficiency than MV99Y at 48, 72 and 96 hpi (P<0.01). Quantitative real-time RT-PCR assays were performed out to assess the virus particle input, including |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Matrix Protein |
| Uniprot protein ID | P35976 |
| Protein length | 335 amino acids |
| Protein description | The M protein is thought to drive MeV assembly by physically recruiting the RNP and glycoproteins to the host cell plasma membrane. Studies have shown that altered interaction between M and the cytoplasmic tail of H or F affects MeV viral growth, indicating the necessity for contacts between M and the glycoproteins during assembly. Recent structural studies of NDV by cryo-ET and X-ray crystallography demonstrated that the RNP complex is aligned with M protein arrays16. Furthermore, it has been suggested that actin filaments play a role in the MeV assembly and budding process by facilitating the transportation of M-RNP complexes. |
Literature information:
| Pubmed ID | 22715352 |
| Clinical information | No |
| Disease | - |
| Published year | 2012 |
| Journal | The Open Virology Journal |
| Title | The E89K Mutation in the Matrix Protein of the Measles Virus Affects In Vitro Cell Death and Virus Replication Efficiency in Human PBMC |
| Author | Jianbao Dong , wei Zhu, Akatsuki Saito, Yoshitaka Goto, Hiroyuki lwata,Takeshi Haga |
| Evidence | The E89K Mutation in the Matrix Protein of the Measles Virus Affects In Vitro Cell Death and Virus Replication Efficiency in Human PBMC |