Mutation detail:
| Mutation site | L25M |
| Virus | Human rhinovirus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | VP3 |
| Gene ID | 1461213 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | B |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_001490.1 |
| Drug/antibody/vaccine | Compound 6g resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Capsid Protein VP3 |
| Uniprot protein ID | P03303 |
| Protein length | 236 amino acids |
| Protein description | VP3 forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome |
Literature information:
| Pubmed ID | 28581749 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | Journal Of Medicinal Chemistry |
| Title | A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication |
| Author | Jinwoo Kim,Yu Kyoung Jung,Chonsaeng Kim,Jin Soo Shin,Els Scheers |
| Evidence | hRV-B14 to find resistant mutations. Interestingly, three 6g - resistant viruses carried the same mutation in the viral capsid protein VP3-L25M |