Mutation detail:
| Mutation site | L94P |
| Virus | Human rhinovirus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | P3C |
| Gene ID | 1461213 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | B |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_001490.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Protease 3C |
| Uniprot protein ID | P03303 |
| Protein length | 182 amino acids |
| Protein description | P3C major viral protease that mediates proteolytic processing of the polyprotein. Cleaves host EIF5B, contributing to host translation shutoff. Cleaves also host PABPC1, contributing to host translation shutoff. Cleaves host NLRP1, triggers host N-glycine-mediated degradation of the autoinhibitory NLRP1 N-terminal fragment. |
Literature information:
| Pubmed ID | 17855535 |
| Clinical information | No |
| Disease | - |
| Published year | 2007 |
| Journal | Journal Of Virology |
| Title | Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex |
| Author | Miaoqing Shen,Qixin Wang,Yan Yang,Harsh B Pathak,Jamie J Arnold |
| Evidence | One mutation changes Leu-94 of 3C to Pro; |