Mutation detail:
| Mutation site | E627K |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | PB2 |
| Gene ID | 23308131 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | FJ966079.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
increase |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Polymerase PB2 |
| Uniprot protein ID | C3W5X5 |
| Protein length | 759 amino acids |
| Protein description | PB2 plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. |
Literature information:
| Pubmed ID | 20140252 |
| Clinical information | No |
| Disease | - |
| Published year | 2010 |
| Journal | PLoS One |
| Title | Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains |
| Author | Olivo Miotto,A T Heiny,Randy Albrecht,Adolfo García-Sastre,Tin Wee Tan |
| Evidence | Remarkably, the two waves only share one conserved H2H mutation (M2 I28V), while all other mutations involved in the 1997 waves have been replaced by avian variants. Thus, it appears that viruses are not only acquiring, but also losing H2H mutations through reassortments. The lack of stability of adaptive variants is evidenced by the instability of the crucial PB2 E627K mutation, implicated in replication in humans and high virulence of human virus infections |