AVM

Protein name	Polymerase PB1
Uniprot protein ID	C3W5X7
Protein length	757 amino acids
Protein description	RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs

Pubmed ID	25122786
Clinical information	No
Disease	-
Published year	2014
Journal	JOURNAL OF VIROLOGY
Title	The Temperature-Sensitive and Attenuation Phenotypes Conferred by Mutations in the Influenza Virus PB2, PB1, and NP Genes Are Influenced by the Species of Origin of the PB2 Gene in Reassortant Viruses Derived from Influenza A/California/07/2009 and A/WSN/
Author	Andrew J. Broadbent,Celia P. Santos,Rachel A. Godbout,Kanta Subbarao
Evidence	The following mutations were made in the WSN, CA07, and VN04 plasmids: PB1-K391E, -E581G, and -A661T and PB2-N265S. In addition, a D34G mutation was made in the WSN NP plasmid and an S34G mutation was made in the VN04 NP plasmid. The CA07 NP plasmid already contained a glycine at amino acid position 34, so it was not necessary to mutate the plasmid.