AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	25328411
Clinical information	No
Disease	-
Published year	2014
Journal	Adv Appl Bioinform Chem
Title	The hemagglutinin of the influenza A(H1N1)pdm09 is mutating towards stability
Author	Juan A Castelan-Vega,Anastasia Magana-Hernandez,Alicia Jimenez-Alberto
Evidence	Recent surveillance data has revealed the emergence of a prominent mutation, E47K (HA2 numbering), in the HA2 stalk region of influenza A(H1N1)pdm09 isolates.This mutation determines the threshold pH of fusion and affects the thermal stability of HA due to intermonomer interactions between HA2 and HA1 in the stalk region of HA.