AVM v1, released 02-OCT-22

A manually curated database of aerosol-transmitted virus mutations, human diseases, and drugs

Mutation detail:


Mutation site L4P
Virus MERS-CoV
Mutation level Amino acid level
Gene/protein/region type ORF8b
Gene ID 19910005
Country -
Mutation type nonsynonymous mutation
Genotype/subtype/clade -
Sample Human
Variants -
Viral reference sequence JX869059.2
Drug/antibody/vaccine -
Transmissibility -
Transmission mechanism -
Pathogenicity -
Pathogenicity mechanism -
Immune escape mutation -
Immune escape mechanism -
RT-PCR primers probes -

Protein detail:


Protein name ORF8b protein
Uniprot protein ID -
Protein length 112 amino acids
Protein description

Literature information:


Pubmed ID 24055451
Clinical information No
Disease -
Published year 2013
Journal Lancet
Title Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study
Author Matthew Cotten,Simon J Watson,Paul Kellam,Abdullah A Al-Rabeeah,Hatem Q Makhdoom
Evidence The EMC/2012 sequence was obtained after extensive cell culture passage to establish a virus isolate;26 there are 76 single nucleotide differences between EMC/2012 and the root of the clade B lineage.Figure 2