AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	26412638
Clinical information	No
Disease	-
Published year	2015
Journal	Iran J Immunol
Title	Antigenic Variation of the Haemagglutinin Gene of the Influenza A (H1N1) pdm09 Virus Circulating in Shiraz, February-April 2013
Author	Forough Tavakoli,Afagh Moattari,Mahmoud Shamsi Shahr Abadi,Mohammad Rahim Kadivar,Nastaran Khodadad
Evidence	In all our study strains, S185T mutation located at the Sb antigenic site and S203T mutation situated within the Ca1 antigenic site occurred. S203T mutation is characteristic of clade 7, therefore, all our strains belonged to clade 7.