Mutation detail:
| Mutation site | 109044C>G |
| Virus | Varicella-Zoster virus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF62 |
| Gene ID | 1487699 |
| Country | - |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | X04370.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Transcriptional Regulator ICP4 |
| Uniprot protein ID | P09310 |
| Protein length | 1310 amino acids |
| Protein description | Native ICP4 is a sequence-specific DNA-binding phosphoprotein that exists in solution as a homodimer. It is found in the nuclei of productively infected cells and in the tegument of mature virions. Transcriptional transactivator may interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. Negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis. |
Literature information:
| Pubmed ID | 10998331 |
| Clinical information | No |
| Disease | - |
| Published year | 2000 |
| Journal | Virology |
| Title | Varicella-Zoster Virus gE Escape Mutant VZV-MSP Exhibits an Accelerated Cell-to-Cell Spread Phenotype in both Infected Cell Cultures and SCID-hu Mice |
| Author | Richard A. Santos,Christopher C. Hatfield,Nancy L. Cole,Jorge A. Padilla,Jennifer F. Moffat |
| Evidence | FIG.7 |