AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	26939538
Clinical information	No
Disease	-
Published year	2016
Journal	Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Title	Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia, Spain
Author	A Antón , M A Marcos, N Torner , R Isanta , M Camps
Evidence	Phylogenetic analyses (HA1 and NA) of 121/123 A(H1N1)pdm09 strains (Table 2; and Supplementary material, Fig. S3), showed that 116 strains were carrying the genetic features (S203T in HA1, and V106I and N248D in NA) of strains belonging to the clade 7 described by Nelson et al.