Mutation detail:
| Mutation site | P269L |
| Virus | Varicella-Zoster virus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF37 |
| Gene ID | 1487668 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | X04370.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Envelope Glycoprotein H |
| Uniprot protein ID | P09260 |
| Protein length | 841 amino acids |
| Protein description | Envelope Glycoprotein H (118 kD) is encoded by open reading frames 37. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. |
Literature information:
| Pubmed ID | 10998331 |
| Clinical information | No |
| Disease | - |
| Published year | 2000 |
| Journal | Virology |
| Title | Varicella-Zoster Virus gE Escape Mutant VZV-MSP Exhibits an Accelerated Cell-to-Cell Spread Phenotype in both Infected Cell Cultures and SCID-hu Mice |
| Author | Richard A. Santos,Christopher C. Hatfield,Nancy L. Cole,Jorge A. Padilla,Jennifer F. Moffat |
| Evidence | FIG.7 |