AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	27515172
Clinical information	No
Disease	-
Published year	2016
Journal	Original Article
Title	Dynamic patterns of circulating influenza virus from 2005 to 2012 in Shandong Province, China
Author	Ti Liu, Zhong Li, Yi Lin, Shaoxia Song, Shengyang Zhang,
Evidence	The HA phylogeny shows that the amino acid substitutions P83S, S203 and I321V were found in all of the Shandong isolates.The substitutions S128P and D86G/Y were identified in 50 % and 30 % of the A/H1N1 pdm09 viruses in the 2009-2010 and 2010-2011 season, respectively.