AVM v1, released 02-OCT-22

A manually curated database of aerosol-transmitted virus mutations, human diseases, and drugs

Mutation detail:


Mutation site A955T
Virus Varicella-Zoster virus
Mutation level Amino acid level
Gene/protein/region type ORF28
Gene ID 1487712
Country -
Mutation type nonsynonymous mutation
Genotype/subtype/clade -
Sample cell line
Variants -
Viral reference sequence X04370.1
Drug/antibody/vaccine -
Transmissibility -
Transmission mechanism -
Pathogenicity -
Pathogenicity mechanism -
Immune escape mutation -
Immune escape mechanism -
RT-PCR primers probes -

Protein detail:


Protein name DNA polymerase catalytic subunit
Uniprot protein ID Q4JQU7
Protein length 1194 amino acids
Protein description DNA polymerase catalytic subunit is the replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).

Literature information:


Pubmed ID 21539861
Clinical information Yes
Disease -
Published year 2011
Journal Antiviral Research
Title Resistance testing of clinical varicella-zoster virus strains
Author Andreas Sauerbrei,Johanna Taut,Roland Zell,Peter Wutzler
Evidence Table4