Mutation detail:
| Mutation site | Y185G |
| Virus | Varicella-Zoster virus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF31 |
| Gene ID | 1487662 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | AB097933.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Envelope Glycoprotein B |
| Uniprot protein ID | P09257 |
| Protein length | 931 amino acids |
| Protein description | Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. |
Literature information:
| Pubmed ID | 19474103 |
| Clinical information | No |
| Disease | - |
| Published year | 2009 |
| Journal | JOURNAL OF VIROLOGY |
| Title | Mutagenesis of Varicella-Zoster Virus Glycoprotein B: Putative Fusion Loop Residues Are Essential for Viral Replication, and the Furin Cleavage Motif Contributes to Pathogenesis in Skin Tissue In Vivo |
| Author | Stefan L. Oliver,Marvin Sommer,Leigh Zerboni,Jaya Rajamani,Charles Grose |
| Evidence | The lack of virus recovery from BACs with the W180 or Y185 point mutation in the putative primary fusion loop demonstrated the importance of this region in VZV gB in the context of virus replication. |