Mutation detail:
| Mutation site | S105T/N130K/L136F |
| Virus | Human rhinovirus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | P3C |
| Gene ID | 1493933 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | A |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | AY751783.1 |
| Drug/antibody/vaccine | rupintrivir resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Protease 3C |
| Uniprot protein ID | P07210 |
| Protein length | 183 amino acids |
| Protein description | P3C major viral protease that mediates proteolytic processing of the polyprotein. P3C cleaves host EIF5B, contributing to host translation shutoff. P3C cleaves also host PABPC1, contributing to host translation shutoff. P3C cleaves host NLRP1, triggers host N-glycine-mediated degradation of the autoinhibitory NLRP1 N-terminal fragment. |
Literature information:
| Pubmed ID | 17908951 |
| Clinical information | No |
| Disease | - |
| Published year | 2007 |
| Journal | Antimicrob Agents Chemother |
| Title | In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 7C protease |
| Author | S L Binford,P T Weady,F Maldonado,M A Brothers,D A Matthews |
| Evidence | Table4 |