Mutation detail:
| Mutation site | E125D |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | NS1 |
| Gene ID | 23308111 |
| Country | USA |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | FJ966086.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nonstructural Protein 1 |
| Uniprot protein ID | C3W611 |
| Protein length | 219 amino acids |
| Protein description | The non-structural protein 1 (NS1) is a crucial influenza A virus immune regulator that antagonizes antiviral response. The NS1 protein counteracts the production of IFNs and the activities of IFN-induced proteins that restrict influenza virus replication. Furthermore, NS1 is a multifunctional regulatory viral protein that plays a critical role as a posttranscriptional regulatory factor in the life cycle of influenza virus; specifically, binding virion RNA. NS1 protein consists of 2 distinct functional domains connected by a flexible linker region (LR): an N-terminal RNA- binding domain (RBD, aa 1-73) and a C-terminal effector domain (ED, aa 74-207). The nucleotide sequence (NLS) (aa 35-41) overlaps the sequences needed for dsRNA binding. |
Literature information:
| Pubmed ID | 28637754 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | J Virol |
| Title | Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N13 Viruses |
| Author | Amelia M Clark,Aitor Nogales,Luis Martinez-Sobrido,David J Topham,Marta L DeDiego |
| Evidence | However, in the case of pH1N1 viruses, the virus encoding the three mutations restoring the ability of NS1 to interact with CPSF30 and to inhibit host gene expression (R108K, E125D, and G189D) was slightly attenuated compared to the pH1N1-wt virus (33). |