Mutation detail:
| Mutation site | 64481C>T |
| Virus | Varicella-Zoster virus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF36 |
| Gene ID | 1487667 |
| Country | The Netherlands |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_001348.1 |
| Drug/antibody/vaccine | acyclovir-resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Thymidine Kinase |
| Uniprot protein ID | P09250 |
| Protein length | 341 amino acids |
| Protein description | Thymidine kinase catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors. |
Literature information:
| Pubmed ID | 23074321 |
| Clinical information | Yes |
| Disease | - |
| Published year | 2013 |
| Journal | Clinical Infectious Diseases |
| Title | Persistence and Antiviral Resistance of Varicella Zoster Virus in Hematological Patients |
| Author | Martha T. van der Beek,1 Clementien L. Vermont,2 Robbert G. M. Bredius,2 Erik W. A. Marijt,3 Caroline S. van der Blij-de Brouwer,1 Aloys C. M. Kroes,1 Eric C. J. Claas,1 and Ann C. T. M. Vossen |
| Evidence | Table4 |