Mutation detail:
| Mutation site | V123I |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | NS1 |
| Gene ID | 23308111 |
| Country | USA |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | FJ966086.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nonstructural Protein 1 |
| Uniprot protein ID | C3W611 |
| Protein length | 219 amino acids |
| Protein description | The non-structural protein 1 (NS1) is a crucial influenza A virus immune regulator that antagonizes antiviral response. The NS1 protein counteracts the production of IFNs and the activities of IFN-induced proteins that restrict influenza virus replication. Furthermore, NS1 is a multifunctional regulatory viral protein that plays a critical role as a posttranscriptional regulatory factor in the life cycle of influenza virus; specifically, binding virion RNA. NS1 protein consists of 2 distinct functional domains connected by a flexible linker region (LR): an N-terminal RNA- binding domain (RBD, aa 1-73) and a C-terminal effector domain (ED, aa 74-207). The nucleotide sequence (NLS) (aa 35-41) overlaps the sequences needed for dsRNA binding. |
Literature information:
| Pubmed ID | 28637754 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | J Virol |
| Title | Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N9 Viruses |
| Author | Amelia M Clark,Aitor Nogales,Luis Martinez-Sobrido,David J Topham,Marta L DeDiego |
| Evidence | On the other hand, Gluc expression was around 2- to 5-fold higher in cells expressing the NS1-6mut proteins containing the K55E, I90L, V123I, D125E, E131K, and S205N single mutations than in cells encoding the NS1-6mut protein, with the K55E mutation showing the least effect (Fig.5D) |