Mutation detail:
| Mutation site | E70K |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | M2 |
| Gene ID | 23308108 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | FJ966085.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Matrix Protein 2 |
| Uniprot protein ID | C3W5X3 |
| Protein length | 97 amino acids |
| Protein description | The M2 protein channel consists of 97 residues: (1) an ectodomain (residues 1-24); (2) the pore-forming TM helix (residues 25-43); (3) an amphiphilic C-terminal helix (residues 47-60); and (4)a cytoplasmic tail (residues 61-97). The influenza A virus M2 protein, a tetrameric type III integral transmembrane (TM) protein, is known to play an essential role in viral replication by mediating the acidification and uncoating of endosomally entrapped virus. The tetrameric M2 in the viral membrane functions as pH-dependent proton channels to equilibrate pH across the viral membrane during entry and across the trans-Golgi membrane of infected cells during viral maturation. |
Literature information:
| Pubmed ID | 28750037 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | PLoS One |
| Title | Generation and characterization of interferon-lambda 1-resistant H1N5 influenza A viruses |
| Author | Natalia A Ilyushina,Vladimir Y Lugovtsev,Anastasia P Samsonova,Faruk G Sheikh,Nicolai V Bovin |
| Evidence | resulted in development of two mutations in HA1 (G155E and S183P, H1 numbering used throughout the text), two mutations in NA (S79L and K331N), one mutation in M2 (E70K), and a single nucleotide mutation T2136C(italic font indicates nucleotide mutation representing silent mutation here and throughout the text) or A183G in PB1 or M1, respectively. Sequence analysis of the genome of the CA/04-IFN-1 virus revealed three mutations in HA1 (G155E, S183P, and M257I), one mutation in M2 (E70K), two nucleotide mutations in PB1 (C975T and T2138C), |