Mutation detail:
| Mutation site | M257I |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | HA |
| Gene ID | 23308115 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | FJ966082.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Hemagglutinin |
| Uniprot protein ID | C3W627 |
| Protein length | 566 amino acids |
| Protein description | The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. |
Literature information:
| Pubmed ID | 28750037 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | PLoS One |
| Title | Generation and characterization of interferon-lambda 1-resistant H1N9 influenza A viruses |
| Author | Natalia A Ilyushina,Vladimir Y Lugovtsev,Anastasia P Samsonova,Faruk G Sheikh,Nicolai V Bovin |
| Evidence | resulted in development of two mutations in HA1 (G155E and S183P, H1 numbering used throughout the text), two mutations in NA (S79L and K331N), one mutation in M2 (E70K), and a single nucleotide mutation T2136C(italic font indicates nucleotide mutation representing silent mutation here and throughout the text) or A183G in PB1 or M1, respectively. Sequence analysis of the genome of the CA/04-IFN-1 virus revealed three mutations in HA1 (G155E, S183P, and M257I), one mutation in M2 (E70K), two nucleotide mutations in PB1 (C975T and T2138C), |