Mutation detail:
| Mutation site | S686A |
| Virus | Varicella-Zoster virus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF62 |
| Gene ID | 1487699 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | AB097933.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Transcriptional Regulator ICP4 |
| Uniprot protein ID | P09310 |
| Protein length | 1310 amino acids |
| Protein description | Native ICP4 is a sequence-specific DNA-binding phosphoprotein that exists in solution as a homodimer. It is found in the nuclei of productively infected cells and in the tegument of mature virions. Transcriptional transactivator may interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. Negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis. |
Literature information:
| Pubmed ID | 26914506 |
| Clinical information | No |
| Disease | - |
| Published year | 2016 |
| Journal | Virology |
| Title | Mutational analysis of varicella-zoster virus (VZV) immediate early protein (IE62) subdomains and their importance in viral replication |
| Author | Mohamed I. Khalil,Xibing Che,Philip Sung,Marvin H. Sommer,John Hay |
| Evidence | In order to generate a DNA fragment encoding both the S686A and S722A mutations, two rounds of PCR were first performed to generate one mutation, and the resulting 1.4kb DNA fragment was used as a template in subsequent two rounds of PCR to generate the s |