Mutation detail:
| Mutation site | A119S |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | N |
| Gene ID | 43740575 |
| Country | Brazil |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | Gamma |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nucleocapsid Phosphoprotein |
| Uniprot protein ID | P0DTC9 |
| Protein length | 419 amino acids |
| Protein description | The Nucleocapsid Phosphoprotein has a modular organization which can be divided into intrinsically disordered regions (IDRs) and conserved structural regions according to the sequence characteristics. The IDRs include three modules: N-arm, central Ser/Arg-rich flexible linker region (LKR), and C-tail, while the conserved structural regions including two modules: N-terminal domain (NTD) and C-terminal domain (CTD). In the primary structure, NTD and CTD are connected by LKR and are usually flanked by N-arm and C-tail. The nucleocapsid phosphoprotein is a structural protein that binds to, protects the viral RNA genome and is involved in packaging the RNA into virus particles. The N protein has been suggested as an antiviral drug target. |
Literature information:
| Pubmed ID | 34363852 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | VIRUS RESEARCH |
| Title | Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021 |
| Author | Vinicius Bonetti Franceschi,Patricia Aline Grohs Ferrareze,Ricardo Ariel Zimerman,Gabriela Bettella Cybis,Claudia Elizabeth Thompson |
| Evidence | A total of 3,919 mutations were detected across the 2,731 Brazilian genomes and only 354 (12.96%) occurred in >5 sequences, 44 (1.61%) in > 50 genomes, and 38 (1.39%) in > 100 sequences (Fig. 2 , Table 1 ). Twenty-five (65.79%) of these 38 mutations were non-synonymous. Of these, 11 (44.0%) were in the spike protein, 5 (20.0%) in the nucleocapsid protein, and 5 (20.0%) in the ORF1ab polyprotein (Table 1). |