Mutation detail:
| Mutation site | S5C |
| Virus | Human rhinovirus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | VP4 |
| Gene ID | 1461213 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | B |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_001490.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Capsid Protein VP4 |
| Uniprot protein ID | P03303 |
| Protein length | 69 amino acids |
| Protein description | VP4 lies on the inner surface of the capsid shell. After binding to the host receptor, the capsid undergoes conformational changes. Capsid protein VP4 is released, Capsid protein VP1 N-terminus is externalized, and together, they shape a pore in the host membrane through which the viral genome is translocated into the host cell cytoplasm. |
Literature information:
| Pubmed ID | 19403680 |
| Clinical information | No |
| Disease | - |
| Published year | 2009 |
| Journal | Journal Of Virology |
| Title | Antibodies to the buried N terminus of rhinovirus VP4 exhibit cross-serotypic neutralization |
| Author | Umesh Katpally,Tong-Ming Fu,Daniel C Freed,Danilo R Casimiro,Thomas J Smith |
| Evidence | The VP4 Ser5Cys mutation did not have any apparent affect on infectivity (e.g., plaque size and particle/PFU ratio); |