Mutation detail:
| Mutation site | P653L |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | PA |
| Gene ID | 23308128 |
| Country | UK |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | GQ166654.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Polymerase PA |
| Uniprot protein ID | C3W5X6 |
| Protein length | 716 amino acids |
| Protein description | PA Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. |
Literature information:
| Pubmed ID | 30352857 |
| Clinical information | No |
| Disease | - |
| Published year | 2018 |
| Journal | Proc Natl Acad Sci U S A |
| Title | The mechanism of resistance to favipiravir in influenza |
| Author | Daniel H Goldhill,Aartjan J W Te Velthuis,Robert A Fletcher,Pinky Langat,Maria Zambon |
| Evidence | Sanger sequencing of the PB1, PB2, and PA genes confirmed the presence of the K229R mutation in PB1 in all four clones and revealed the presence of an additional proline 653 to leucine mutation (P653L) in the PA subunit in all four clones. |