AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	30429836
Clinical information	No
Disease	-
Published year	2018
Journal	Frontiers in microbiology
Title	Seasonal Genetic Drift of Human Influenza A Virus Quasispecies Revealed by Deep Sequencing
Author	Cyril Barbezange,Louis Jones,Herve Blanc,Ofer Isakov,Gershon Celniker
Evidence	Thus, for pH1N1, mutations A134T/S183P in the HA and Q313R/V394I in the NA, that we identified as minority mutations during the 2010-2011 season, were used the following season by WHO Collaborating Centers (Barr et al., 2014) to define group 3 sequences (represented by A/Hong-Kong/3934/2011). Similarly, mutations S143G/A197T in the HA and N44S in the NA were used to define group 7 sequences (represented by A/St-Petersburg/100/2011).