Mutation detail:
| Mutation site | 23583-23597delATCAGACTCAGACTA |
| Virus | SARS-CoV-2 |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | - |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | MN908947.3 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
decrease |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 32571797 |
| Clinical information | No |
| Disease | - |
| Published year | 2020 |
| Journal | JOURNAL OF VIROLOGY |
| Title | Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2 |
| Author | Zhe Liu, Huanying Zheng, Huifang Lin, Mingyue Li, Runyu Yuan |
| Evidence | After mapping sequences to the SARS-CoV-2 reference genome (GenBank accession number MN908947.3), we found that there were two variants in the cell-isolated viral strain with deletions at (i) positions 23583 to 23597 (Var1), flanking the polybasic cleavage site, resulting in a QTQTN deletion in the spike protein (one amino acid before the polybasic cleavage site); and (ii) positions 23597 to 23617 (Var2), resulting in a NSPRRAR deletion that includes the polybasic cleavage site (Fig. 1A) |