Mutation detail:
| Mutation site | 1938G>A |
| Virus | Human respiratory syncytial virus |
Mutation level  |
Nucleotide Level |
| Gene/protein/region type | N |
| Gene ID | 1494470 |
| Country | - |
| Mutation type |
- |
| Genotype/subtype/clade | A |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | M74568.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nucleoprotein |
| Uniprot protein ID | P03418 |
| Protein length | 391 amino acids |
| Protein description | Nucleoprotein Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases. RNA replication depends on the availability of soluble nucleoprotein. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway. May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs. |
Literature information:
| Pubmed ID | 10195777 |
| Clinical information | No |
| Disease | - |
| Published year | 1999 |
| Journal | Vaccine |
| Title | The two amino acid substitutions in the L protein of cpts530/1009, a live-attenuated respiratory syncytial virus candidate vaccine, are independent temperature-sensitive and attenuation mutations |
| Author | K Juhasz, S S Whitehead, C A Boulanger, C Y Firestone, P L Collins |
| Evidence | Table 1 |