Mutation detail:
| Mutation site | T154I |
| Virus | Human rhinovirus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | P3C |
| Gene ID | 1461213 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | B |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_001490.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Protease 3C |
| Uniprot protein ID | P03303 |
| Protein length | 182 amino acids |
| Protein description | P3C major viral protease that mediates proteolytic processing of the polyprotein. Cleaves host EIF5B, contributing to host translation shutoff. Cleaves also host PABPC1, contributing to host translation shutoff. Cleaves host NLRP1, triggers host N-glycine-mediated degradation of the autoinhibitory NLRP1 N-terminal fragment. |
Literature information:
| Pubmed ID | 8245010 |
| Clinical information | No |
| Disease | - |
| Published year | 1993 |
| Journal | Journal Of Biological Chemistry |
| Title | Human rhinovirus-14 protease 3C (3Cpro) binds specifically to the 5'-noncoding region of the viral RNA. Evidence that 8Cpro has different domains for the RNA binding and proteolytic activities |
| Author | L E Leong,P A Walker,A G Porter |
| Evidence | as the mutations T154I or K156R gave second site revertants restoring 3CP" binding to mutated 5'-NCR sequences (12, 13). In HRV-14 3CPm |