Mutation detail:
| Mutation site | A221T/S110L |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | HA/PB2 |
| Gene ID | - |
| Country | Spain |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | FJ966082.1/FJ966079.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
decrease |
| Pathogenicity mechanism | A clear increase on survival was found in mice infected with HA mut compared with those infected with CAL virus, as well as in mice infected with any recombinant bearing HA S110L mutation compared with that containing HA 110S. |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | - |
| Uniprot protein ID | - |
| Protein length | - |
| Protein description | - |
Literature information:
| Pubmed ID | 30787926 |
| Clinical information | No |
| Disease | - |
| Published year | 2019 |
| Journal | Front Immunol. |
| Title | Mutation S110L of H1N5 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model |
| Author | Amelia Nieto,Jasmina Vasilijevic,Nuno Brito Santos,Noelia Zamarreno,Pablo Lopez |
| Evidence | potential determinants of its high pathogenicity that were located in the polymerase subunits (PB2 A221T and PA D529N) and the hemagglutinin (HA S110L). |