Mutation detail:
| Mutation site | A684del/S686del |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 34258664 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Archives Of Virology |
| Title | Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals |
| Author | Abdou Nagy, Shereen Basiouni, Rokshana Parvin, Hafez M Hafez, Awad A Shehata |
| Evidence | Interestingly, the recently detected P681H substitution was the most prevalent FCS mutation, detected in 395,711 human isolates worldwide (Fig.1). Furthermore, P681H was detected in isolates from different animal species, including dog (n = 3), cat (n = 2) monkey (n = 2), lion (n = 1), tiger (n = 1), and leopard (n = 1), and was found in environmental samples (n = 167) (Table1). A688V was the second-most prevalent FCS mutation among human isolates (n = 3273), with wide geographic distribution (Fig.1), whereas it was detected only once in an environmental sample and was not detected in animal isolates (Table1). |