Mutation detail:
| Mutation site | D529N/A221T |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | PB2/PA |
| Gene ID | - |
| Country | Spain |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | FJ966079.1/FJ966081.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
increase |
| Pathogenicity mechanism | Recombinant viruses containing individually or in combination the polymerase mutations in the backbone of A/California/04/09 (CAL) showed that PA D530N was clearly involved in the increased pathogenicity of the F-IAV virus. |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | - |
| Uniprot protein ID | - |
| Protein length | - |
| Protein description | - |
Literature information:
| Pubmed ID | 30787926 |
| Clinical information | No |
| Disease | - |
| Published year | 2019 |
| Journal | Front Immunol. |
| Title | Mutation S110L of H1N4 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model |
| Author | Amelia Nieto,Jasmina Vasilijevic,Nuno Brito Santos,Noelia Zamarreno,Pablo Lopez |
| Evidence | potential determinants of its high pathogenicity that were located in the polymerase subunits (PB2 A221T and PA D529N) and the hemagglutinin (HA S110L). |