Mutation detail:
| Mutation site | D529N/S110L |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | HA/PA |
| Gene ID | - |
| Country | Spain |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | FJ966082.1/FJ966081.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
decrease |
| Pathogenicity mechanism | This fact even occurs in the case of mice infected with a recombinant virus that also contains PA D529N mutation that works as an extremely pathogenicity determinant (Figure 5B compared PA mut and PA/HA mut) indicating that HA S110L change is a very poten |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | - |
| Uniprot protein ID | - |
| Protein length | - |
| Protein description | - |
Literature information:
| Pubmed ID | 30787926 |
| Clinical information | No |
| Disease | - |
| Published year | 2019 |
| Journal | Front Immunol. |
| Title | Mutation S110L of H1N6 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model |
| Author | Amelia Nieto,Jasmina Vasilijevic,Nuno Brito Santos,Noelia Zamarreno,Pablo Lopez |
| Evidence | potential determinants of its high pathogenicity that were located in the polymerase subunits (PB2 A221T and PA D529N) and the hemagglutinin (HA S110L). |