Mutation detail:
| Mutation site | 33646G>A |
| Virus | Varicella-Zoster virus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF21 |
| Gene ID | 1487686 |
| Country | Ireland |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | X04370.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Tegument Protein UL37 |
| Uniprot protein ID | P09277 |
| Protein length | 1038 amino acids |
| Protein description | UL37 is a highly conserved tegument protein that has activities ranging from virion morphogenesis to directional capsid trafficking to manipulation of the host innate immune response and binds multiple partners. The N-terminal half of UL37 has a compact bean-shaped α-helical structure that contains a surface region essential for neuroinvasion. The inner tegument protein UL37 plays multiple roles in the viral replication cycle. Along with UL36, which is directly bound to the viral capsid, UL37 initiates tegument accumulation on the capsid during virion assembly and forms filamentous structures that may serve as a scaffold for the outer tegument proteins. |
Literature information:
| Pubmed ID | 15042660 |
| Clinical information | No |
| Disease | - |
| Published year | 2004 |
| Journal | Journal of Medical Virology |
| Title | Genetic Variation in Clinical Varicella-Zoster Virus Isolates Collected in Ireland Between 2002 and 2003 |
| Author | Michael J. Carr,1 Grace P. McCormack,2 and Brendan Crowley |
| Evidence | Table3 |