Mutation detail:
| Mutation site | A99S |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF3a |
| Gene ID | 43740569 |
| Country | Indonesia |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF3a protein |
| Uniprot protein ID | P0DTC3 |
| Protein length | 275 amino acids |
| Protein description | ORF3a is a non-structural protein of SARS-CoV-2 localized at the surface. It is the largest accessory factor that contains 275 amino acids, and shows broad functions, such as enhancing viral entry within the host, regulating the pro-inflammatory cytokine and chemokine production, participating in ion channel formation as well as modulating release of virus from the host cell. |
Literature information:
| Pubmed ID | 34074255 |
| Clinical information | Yes |
| Disease | - |
| Published year | 2021 |
| Journal | BMC Medical Genomics |
| Title | Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters |
| Author | Gunadi,Hendra Wibawa,Mohamad Saifudin Hakim,Marcellus,Ika Trisnawati |
| Evidence | Ninety-four SNPs were detected throughout the ORP of the SARS-CoV-2 virus samples with 60% (54/94) of the nucleic acid changes resulting in amino acid substitutions (missense mutations) (Table1,1, detailed in Additional file 1: Table S1). |