Mutation detail:
| Mutation site | 87847C>T |
| Virus | Varicella-Zoster virus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF50 |
| Gene ID | 1487658 |
| Country | Ireland |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | X04370.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Envelope Glycoprotein M |
| Uniprot protein ID | Q77NP2 |
| Protein length | 435 amino acids |
| Protein description | The ORF50 gene of the varicella-zoster virus (VZV) encodes glycoprotein M (gM), which is conserved among all herpesviruses and is important for the cell-to-cell spread of VZV. Important features are its 6-8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. |
Literature information:
| Pubmed ID | 15042660 |
| Clinical information | No |
| Disease | - |
| Published year | 2004 |
| Journal | Journal of Medical Virology |
| Title | Genetic Variation in Clinical Varicella-Zoster Virus Isolates Collected in Ireland Between 2002 and 2003 |
| Author | Michael J. Carr,1 Grace P. McCormack,2 and Brendan Crowley |
| Evidence | Table3 |