Mutation detail:
| Mutation site | C81R |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF3a |
| Gene ID | 43740569 |
| Country | India |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | MN908947.3 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF3a protein |
| Uniprot protein ID | P0DTC3 |
| Protein length | 275 amino acids |
| Protein description | ORF3a is a non-structural protein of SARS-CoV-2 localized at the surface. It is the largest accessory factor that contains 275 amino acids, and shows broad functions, such as enhancing viral entry within the host, regulating the pro-inflammatory cytokine and chemokine production, participating in ion channel formation as well as modulating release of virus from the host cell. |
Literature information:
| Pubmed ID | 34518554 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Scientific Reports |
| Title | Emergence and expansion of highly infectious spike protein D614G mutant SARS-CoV-2 in central India |
| Author | Shashi Sharma,Paban Kumar Dash,Sushil Kumar Sharma,Ambuj Srivastava,Jyoti S Kumar |
| Evidence | The amino acid substitutions were found scattered throughout the genome. A total of 38 amino acid substitutions were observed compared to prototype Wuhan strain. Out of these, 24 were found in ORF1ab, 5 in the S protein, 2 in ORF 3a, 1 each in E, M and ORF 7a. Finally, 4 substitutions were located in the N protein. The unique non-synonymous variants from all samples are shown in Table 22. |