AVM

Protein name	Nucleocapsid Protein
Uniprot protein ID	C3W621
Protein length	498 amino acids
Protein description	NP encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.

Pubmed ID	31044563
Clinical information	No
Disease	-
Published year	2019
Journal	FEBS J
Title	Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-7 mediated nuclear import pathway
Author	Patricia Resa-Infante,Jaume Bonet,Swantje Thiele,Malik Alawi,Stephanie Stanelle-Bertram
Evidence	We show that three mutations in particular occur with high frequency in the viral nucleoprotein (NP) protein (G102R, M105K and D375N) in a specific structural area upon in vivo adaptation.