Mutation detail:
| Mutation site | A674E |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | PB2 |
| Gene ID | 23308131 |
| Country | Russia |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | clade 6B |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | MK622939.1 |
| Drug/antibody/vaccine | zanamivir |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Polymerase PB2 |
| Uniprot protein ID | C3W5X5 |
| Protein length | 759 amino acids |
| Protein description | PB2 plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. |
Literature information:
| Pubmed ID | 31356626 |
| Clinical information | Yes |
| Disease | - |
| Published year | 2019 |
| Journal | PLoS One |
| Title | Severe cases of seasonal influenza in Russia in 2017-2018 |
| Author | Natalia P Kolosova,Tatyana N Ilyicheva,Alexey V Danilenko,Julia A Bulanovich,Svetlana V Svyatchenko |
| Evidence | S1 Table. Amino acid substitutions in genomes of A(H1N1)pdm2009 viruses in comparison with the A/Michigan/45/2015 vaccine strain. |