AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	31356626
Clinical information	Yes
Disease	-
Published year	2019
Journal	PLoS One
Title	Severe cases of seasonal influenza in Russia in 2017-2018
Author	Natalia P Kolosova,Tatyana N Ilyicheva,Alexey V Danilenko,Julia A Bulanovich,Svetlana V Svyatchenko
Evidence	S1 Table. Amino acid substitutions in genomes of A(H1N1)pdm2009 viruses in comparison with the A/Michigan/45/2015 vaccine strain.