AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	20554779
Clinical information	No
Disease	-
Published year	2010
Journal	J Virol
Title	Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N2 influenza virus
Author	Xiangjie Sun,Longping V Tse,A Damon Ferguson,Gary R Whittaker
Evidence	According to the manufacturer's protocol, pairs of complementary oligonucleotides were designed to introduce the desired mutations. The sequences of the HA gene for the wild-type (Y328) and mutant (Y328F and Y328S) forms of HA were confirmed by sequencing using an Applied Biosystems Automated 3730 DNA Analyzer at the Cornell University Life Sciences Core Laboratories Center.